Prelims 2021 · Science and Technology · Question 66
In the context of hereditary diseases, consider the following statements:<br/>1. Passing on mitochondrial diseases from parent to child can be prevented by mitochondrial replacement therapy either before or after in vitro fertilization of egg.<br/>2. A child inherits mitochondrial diseases entirely from mother and not from father.<br/><br/>Which of the statements given above is/are correct?
Answer
Both 1 and 2
Correct. Mitochondrial replacement therapy (MRT) is used to prevent transmission of defective maternal mitochondria; techniques exist before fertilization (maternal spindle transfer) and after fertilization (pronuclear transfer).
Correct. Mitochondrial DNA is inherited almost entirely from the mother because the embryo’s mitochondria come from the ovum; paternal mitochondria are typically not transmitted.
Therefore, both statements are correct.