Civil Services Prep

Prelims 2020 · Science and Technology · Question 17

In the context of recent advances in human reproductive technology, "Pronuclear Transfer" is used for

  1. fertilization of egg in vitro by the donor sperm
  2. genetic modification of sperm producing cells
  3. development of stem cells into functional embryos
  4. prevention of mitochondrial diseases in offspring

Answer

prevention of mitochondrial diseases in offspring

  • (a) Pronuclear transfer is not simply IVF using donor sperm. It is a specialized embryo-manipulation technique after fertilization. Verdict: Incorrect.
  • (b) It does not involve genetic modification of sperm-producing cells. The technique transfers nuclear genetic material between zygotes. Verdict: Incorrect.
  • (c) It is not about converting stem cells into functional embryos. That is a different area of developmental biology. Verdict: Incorrect.
  • (d) In pronuclear transfer, the pronuclei from intended parents are moved into a donor egg/zygote with healthy mitochondria, helping avoid transmission of mitochondrial disorders. Verdict: Correct.
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